The film starts six months after the Rage virus has spread throughout
the city of London. The United States Army has restored order and is
repopulating the quarantined city, when a carrier of the Rage virus enters
London and unknowingly re-ignites the spread of the deadly infection,
wreaking havoc on the entire population.

Don and his wife Alice are living alongside a group of survivors in a
heavily reinforced cottage somewhere in Rage infected Britain. They are
eating a meal when a young boy is heard outside shouting and banging on the
house. Against his better judgement, Don opens the door to let in the
frightened child, who had escaped a horde of infected. The infected soon
discover the hideout and break their way in, overwhelming the group quickly.
Don is separated from his wife (who was trying to rescue the child) and
flees down a river in a small motor boat, the only survivor of the group.